Present Status of LIGAND Chemical Database for Enzyme Reactions

LIGAND Chemical Database for Enzyme Reactions was originally designed to link structural aspects of enzymatic proteins to chemical aspects of enzymatic reactions . It has accumulated all known enzymes classi ed according to the EC numbers given by the International Union of Biochemistry and Molecular Biology (IUBMB) and has been integrated within the DBGET/LinkDB system with protein structure databases. Enzymatic reaction catalyzed by each enzyme is given by the chemical equation and by the chemical names of the substrates, products, and inhibitors of the reaction. LIGAND has provided a various approach to the analysis of structure-function relationships of enzymes such as the extraction of the amino acid sequence motifs responsible for the substrate speci city of the enzymes (Suyama et al., 1995). The present paper show the present status of the LIGAND.